基本信息

姓 名：尤征英    

手 机: 13989832857          邮箱:youzhengying85@163.com

zyyou@zstu.edu.cn

个人简介：

尤征英，理学博士，特聘副教授。2015年毕业于浙江大学，生物化学与分子生物学专业，获得理学博士。2015.11-2018.04在浙江大学从事博士后研究，主要方向：基于piggyBac家蚕转基因系统和基因编辑技术改良家蚕丝纤维的性能和家蚕丝腺高效表达蛋白的机制研究。2018年04月起，就职于太阳成集团tyc151cc，从事教学科研工作。目前，主持国家自然科学基金青年基因1项、中国博士后科学基金1项、国家重点实验室开放课题1项；参与国家自然科学基金1项和浙江省青年基金各1项。共同发表论文20余篇。

科研项目

1． 家蚕合成分泌优异家蚕/蜘蛛丝复合丝纤维的研究，国家自然科学基金青年基金项目，31702183，22万，2018.01 - 2020.12. 主持

2． 转蜘蛛牵引丝蛋白蚕丝优异性能的分子机理的探索，中国博士后科学基金，编号2016M591989, 5万元，2016.05-2017.10. 主持

3． 探索家蚕丝蛋白基因高效表达调控机理的研究，太阳成集团tyc151cc科研启动项目，11612932618138，15万元2018.06-2023.06. 主持

4.  蛋白泛素化修饰异常与家蚕裸蛹的关系研究，国家自然科学基金，31772676，2018.01-2021.12，排名2/7. 参与

5. 家蚕丝腺生物反应器生产人血清白蛋白技术的开发和应用，浙江省科技厅项目, 编号2013C32048， 2013.7-2015.12，排名3/7. 参与.

6. 蚕丝蛋白合成分子调控与蚕丝品质形成机理解析， 973课题，编号2012CB114601，2012.1-2016.10，排名7/38. 参与.

发表论文（以第一作者或通讯作者发表的主要论文^#第一作者标注，*通讯作者）:

1. Jiasheng Geng, Weina Lu, Qinglong Kong, Jiao Lv, Yue Liu, Guowei Zu, Yanmei Chen, Caiying Jiang, Zhengying You*, Zuoming Nie*. Validation of selective catalytic BmCBP inhibitors that regulate the Bm30K-24 protein expression in silkworm, Bombyx mori. Insect Mol Biol. 2025, 34(2): 322–334.（*通讯作者）

2. Xiao Chang, Jie Li, Shengnan Wei, Jianan Ying, Paul Nevill, Zhechen Qi, Qixiang Lu*, Zhengying*. Integrated comparative transcriptome and weighted gene co-expression network analysis provide valuable insights into the response mechanisms of Alisma orientale to cadmium stress. Science of the Total Environment. 2024, 957, 177401.（*通讯作者）

3. Huanhuan Wen, Yanan Wang, Yongqiang Ji, Jing Chen, Yao Xiao, Qixiang Lu, Caiying Jiang, Qing Sheng, Zuoming Nie and Zhengying You*. Effect of acute exposure of Hg on physiological parameters and transcriptome expression in silkworms (Bombyx mori). Front. Vet. Sci, 2024,11. (*通讯作者)

4. Yule Cai^#, Ziyi Wu^#, Xiangxiang Li, Xingting Hu, Jiamin Wu, Zhengying You * and Jieqiong Qiu *. Comparison of Double-Stranded DNA at the 5′and 3′Ends of the G-Triplex and Its Application in the Detection of Hg (II). Int J Mol Sci. 2024, 24, 8159. (*通讯作者)

5. Yao Xiao^#, Lujie Ren^#, YananWang, Huanhuan Wen, Yongqiang Ji, Chenshou Li, Yangqing Yi, Caiying Jiang, Qing Sheng, Zuoming Nie, Qixiang Lu and Zhengying You*. Biochemical Characterization and Functional Analysis of Glucose Regulated Protein 78 from the Silkworm Bombyx mori. Int J Mol Sci. 2023, 24(4), 3964. (*通讯作者)

6. Qi Xiang Lu^#, Lu Jie Ren^#, Ya Nan Wang, Yao Xiao, Yu Dong Li, Jia Nan Ying, Ying Zhang, Ruihong Wang, Zhe Chen Qi and Zheng Ying You*. Characterization of the complete chloroplast genome of Sparganium glomeratum (Typhaceae) from Jilin Province, China and phylogenetic analysis. MITOCHONDRIAL DNA B, 2021, 6(11), 3253-3254. (*通讯作者)

7. Zhengying You, Xiaogang Ye, Lupeng Ye, Qiujie Qian, Meiyu Wu, Jia Song, Jiaqian Che, Boxiong Zhong*. Extraordinary Mechanical Properties of Composite Silk Through Hereditable Transgenic Silkworm Expressing Recombinant Major Ampullate Spidroin. Scientific Reports, 2018 29; 8(1):15956.

8. Qiujie Qian^#, Zhengying You^#, Lupeng Ye, Jiaqian Che,Yiran Wang, Shaohua Wang, Boxiong Zhong*. High-efficiency production of human serum albumin in the posterior silk glands of transgenic silkworms, Bombyx mori L. PloS One, 2018, 13(1): e0191507.

9. Zhengying You, Qiujie Qian, Yiran Wang, Jiaqian Che, Lupeng Ye, Lirong Shen*, Boxiong Zhong* Transgenic silkworms secrete the recombinant glycosylated MRJP1 protein of Chinese honeybee, Apis cerana cerana. Transgenic Res, 2017 Aug 11. doi: 10.1007/s11248-017-0034-1.

10. Shaohua Wang^#, Zhengying You^#, Mao Feng, Jiaqian Che, Yuyu Zhang, Qiujie Qian, Setsuko Komatsu*, Boxiong Zhong*. Analyses of the molecular mechanisms associated with silk production in silkworm by iTRAQ-based proteomics and RNA-sequencing-based transcriptomics. Journal of proteome research, 2016 15(1):15-28.