个人简介：

李恭楚，教授、博士生导师，杭州功楚生物科技有限公司联合创始人、首席科学家。长期从事溶瘤病毒的基础与应用研究，发现了全新的调控溶瘤痘苗病毒的细胞内途径，并成功将其应用于药物研发。其领衔的团队成果“溶瘤痘苗病毒改造技术”以1750万元技术作价入股，成立杭州功楚生物科技有限公司，成为浙江省属高校作价投资千万级的首例，也是高校科技成果以技术作价入股方式实现产业化开发的典型案例。其研发的溶瘤痘苗病毒（GC001）注射液具有全新靶点与独特机制，抗肿瘤能力显著优于国际同类产品，达到国际领先水平。该产品已获两项临床批件（受理号：CXSL2300689、CXSL2200569）。李恭楚主持国家自然科学基金项目2项、浙江省自然科学基金重点项目1项及多项横向项目。在溶瘤病毒研究领域，尤其在溶瘤痘苗病毒的调控方面，取得多项源头创新成果，获浙江省科技进步奖三等奖1项、中国商业联合会科技进步奖二等奖1项。此外，已授权国家发明专利5项、国际专利1项，担任多家国际期刊审稿人、法国国家科研署项目评审人以及浙江省自然科学基金委的答辩评审专家。

学习经历

1. 纽约州立大学宾汉姆顿分校生物科学系博士

2. 华东师范老员工物学系 学士、硕士

近三年发表论文：

1. Xiao D, Zhang H, Liu Y, Li Y*, Li G*, Ning Y*. Oncolytic viruses: advanced strategies in cancer

therapy. Signal Transduct Target Ther. 2026 Feb 5;11(1):45.

2. Zhang H, Pang W, Zhou J, Ye T, Chen K, Zhou Y*, Li G*. Comparison between Western Reserve strain and Tiantan strain of oncolytic vaccinia virus vector expressing exogenous gene Aphracilistes vastus lectin. Biochem Biophys Res Commun. 2025 Aug 15;775:152155.

3. Wang Q, Zhou S, Wang Y, Gao Y, Zhou Y, Ye T, Li G*, Chen K*. An Oncolytic Vaccinia Virus Expressing Aphrocallistes Vastus Lectin Modulates Hepatocellular Carcinoma Metabolism via ACSS2/TFEB-Mediated Autophagy and Lipid Accumulation. Mar Drugs. 2025 Jul 24;23(8):297.

4. Cai Z, Hong Z, Zhang G, Zhu T, Zhou Y, Ye T, Li G*, Chen K*. Oncolytic Vaccinia Virus Expressing HSP70 shRNA Exerts Anti-Tumor Effects in Human Ovarian Cancer via Triggering the Autophagy-ROS Feedback Loop and Immune Activation. Viruses. 2025 Oct 27;17(11):1423

5. Yu J, An N, Zhu J, Zhu B, Zhang G, Chen K, Zhou Y, Ye T*, Li G*. AVL-armed oncolytic vaccinia virus promotes viral replication and boosts antitumor immunity via increasing ROS levels in pancreatic cancer. Mol Ther Oncol. 2024 Sep 17;32(4):200878.

6. Gao C, Ying Q, Qiu Y, Ren N, Chen K, Zhou Y, Ye T*, Li G*. Oncolytic vaccinia virus harboring CLEC2A gene enhances viral replication and antitumor efficacy. Mol Ther Oncol. 2024 Jun 5;32(3):200823.

7. Zhang G, Wang Q, Yuan R, Zhang Y, Chen K, Yu J, Ye T, Jia X, Zhou Y, Li G*, Chen K*. Oncolytic vaccinia virus harboring aphrocallistes vastus lectin exerts anti-tumor effects by directly oncolysis and inducing immune response through enhancing ROS in human ovarian cancer. Biochem Biophys Res Commun. 2024 Oct 20;730:150355.

8. Zhu B, Hong Z, Zhu J, Yu J, Zhou Y, Chen K, Ye T*, Li G*. Oncolytic Vaccinia Virus Encoding Aphrocallistes vastus Lectin Suppresses the Proliferation of Gastric Cancer Cells. Hum Gene Ther. 2024 Nov;35(21-22):938-950.

9. Zhang Y, Zhu Y, Jiang G, Chen K, Zhang G, Chen K, Ye T, Zhou Y*, Li G*. ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells. Mar Drugs. 2024 Jun 30;22(7):307.

10. Zhou Y, Wang Q, Ying Q, Zhang X, Chen K, Ye T*, Li G*. Effects of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins on Hepatocellular Carcinoma Cells. Int J Mol Sci. 2023 Feb 14;24(4):3823.