周燕蓉，理学博士，讲师，硕士生导师，博士毕业于山东大学微生物技术国家重点实验室微生物学专业。主持国家自然科学基金青年项目、浙江省自然科学基金青年项目、浙江省教育厅一般项目和微生物技术国家重点实验室开放课题重点项目等，参与多项国家级科研项目。以第一作者或通讯作者在相关领域发表多篇SCI科研论文，参与获得2项国家发明专利。指导本科生荣获包含全国老员工生命科学竞赛二等奖在内的省部级以上学科竞赛奖励2项。

邮箱：zhouyanrong@zstu.edu.cn

研究方向

肿瘤细胞的代谢重编程

基于溶瘤病毒的抗肿瘤药物相关研究

科研项目

国家自然科学基金项目（青年）               2025 - 2027   1/1

浙江省自然科学基金项目（青年）             2024 - 2026  1/1

浙江省教育厅一般项目                       2023 - 2025    1/2

微生物技术国家重点实验室开放课题重点项目   2023 - 2025  1/5

国家自然科学基金面上项目   2021 - 2024 参与

国家自然科学基金面上项目     2020 - 2023   参与

国家自然科学基金重大研究计划 2019 - 2022 参与

科研论文

Yanan Zhang, Ying Zhu, Gaohui Jiang, Ke Chen, Guohui Zhang, Kan Chen, Ting Ye, Yanrong Zhou*, Gongchu Li*. ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells. Marine drugs, 2024, 22(7), 307.

Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Kan Chen, Ting Ye, Gongchu Li. Effects of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins on Hepatocellular Carcinoma Cells. International journal of molecular sciences, 2023, 24(4): 3823.

Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Kan Chen, Ting Ye, Gongchu Li. A Comparative Study of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins in Breast Cancer Cells. Marine Drugs. 2023, 21(2): 77.  

Yanrong Zhou, Xiaoyan Song, Yue Li, Jinchao Shi, Weiling Shi, Xiulan Chen, Weifeng Liu, Xiangmei Liu, Weixin Zhang*, Yuzhong Zhang*. Enhancing peptaibols production in the biocontrol fungus Trichoderma longibrachiatum SMF2 by elimination of a putative glucose sensor. Biotechnology and Bioengineering, 2019, 116(11): 3030-3040.

Jinchao Shi^#, Weiling Shi^#, Yanrong Zhou^#, Xiulan Chen, Yuzhong Zhang, Xia Zhang*, Weixin Zhang*, Xiaoyan Song*. The Putative Methyltransferase TlLAE1 is Involved in the Regulation of Peptaibols Production in the Biocontrol Fungus Trichoderma longibrachiatum SMF2. Frontiers in Microbiology, 2020, 11: 1267.

Jianlei Yu, Nan An, Jili Zhu, Borong Zhu, Guohui Zhang, Kan Chen, Yanrong Zhou, Ting Ye*, and Gongchu Li*. AVL-armed oncolytic vaccinia virus promotes viral replication and boosts antitumor immunity via increasing ROS levels in pancreatic cancer. Molecular therapy. Oncology, 2024,32(4)

Borong Zhu, Zhiyun Hong, Jili Zhu, Jianlei Yu, Yanrong Zhou, Kan Chen, Ting Ye*, and Gongchu Li*. Oncolytic Vaccinia Virus Encoding Aphrocallistes vastus Lectin Suppresses the Proliferation of Gastric Cancer Cells. Human gene therapy, 2024.

Guohui Zhang, Qiang Wang, Rentao Yuan, Yanan Zhang, Ke Chen, Jianlei Yu, Ting Ye, Xiaoyuan Jia, Yanrong Zhou, Gongchu Li*, Kan Chen*. Oncolytic vaccinia virus harboring aphrocallistes vastus lectin exerts anti-tumor effects by directly oncolysis and inducing immune response through enhancing ROS in human ovarian cancer.

Chunqing Gao, Qi Ying, Yufeng Qiu, Ningbo Ren, Kan Chen, Yanrong Zhou, Ting Ye* and Gongchu Li*. Oncolytic vaccinia virus harboring CLEC2A gene enhances viral replication and antitumor efficacy. Molecular therapy. Oncology, 2024, 32(3), 200823.

Jianing Chen, Lin Xu, Yanrong Zhou, Bingnan Han. Natural Products from Actinomycetes Associated with Marine Organisms. Marine Drugs, 2021, 19(11): 629.

专利

1. 张玉忠,陈秀兰,周燕蓉,宋晓妍,张熙颖,解彬彬,苏海楠. 一株高产peptaibols抗菌肽的ΔTlrgt2木霉工程菌及其构建方法与应用,已授权,专利号：ZL 2018 1 1169375.5.

2. 张玉忠,宋晓妍,时金超,周燕蓉,刘白雪,陈秀兰,刘巍峰,解彬彬,李平一,李春阳. 一株过表达lae1基因的木霉工程菌及其构建方法与应用,已授权,专利号：ZL 2016 1 0899151.4.