庄原

性 别：女

出生年月：1992年09月

职称：讲师

学科组：植物学与药用资源学

办公室：19号楼813室

电话：13164620423

电子邮件：zhuangyuan@zstu.edu.cn

主要学习工作经历：

1. 2010.09–2014.06 华中科技大学 化学与化工学院 学士 应用化学专业

2. 2014.09–2019.09 华中科技大学 化学与化工学院 博士 高分子化学与物理专业

3. 2020.01–2022.04 清华大学 化学系 博士后

4. 2022.05–2022.08 中国科学院化学研究所 科研助理

5. 2022.08–2024.12 中国人民解放军海军军医大学 药学系 讲师

6. 2025.01–现   在 太阳成集团tyc151cc 太阳成集团tyc151cc 讲师

主要研究方向：

1. 药用植物毒性物质动态监测策略设计；

2. 药用植物活性物质精准调控范式构建。

SCI期刊论文发表情况：

1. H. Yu^†, F. Lan^†, Y. Zhuang^†, Q. Li^†, L. Zhang^†, H. Tian, X. Bu, R. Chen, Y. Gao, Z. Wang*, L. Zhang*. Paclitaxel Anti-Cancer Therapeutics: From Discovery to Clinical Use. Chinese Journal of Natural Medicines 2025, DOI: 10.1016/S1875-5364(25)60833-8. (co-author)

2. Y. Zhang, X. Hou, J. Piao, W. Yuan, B. Zhou, X. Zhao, Z. Hao*, Y. Zhuang*, L. Xu*, Y. Dong*, D. Liu. Delivery and Controllable Release of Anti-Sense DNA Based on  Frame-Guided Assembly Strategy. Eur. Polym. J. 2022, 173, 111187.

3. Y. Zhuang, L. Li, L. Feng, S. Wang, H. Su, H. Liu, H. Liu*, Y. Wu*. Mitochondrion-Targeted Selenium Nanoparticles Enhance Reactive Oxygen Species-Mediated Cell Death. Nanoscale 2020, 12 (3), 1389−1396.

4. Y. Zhuang^†, C. Shang^†, X. Lou*, F. Xia*. Construction of AIEgens-Based Bioprobe with Two Fluorescent Signals for Enhanced Monitor of Extracellular and Intracellular Telomerase Activity. Anal. Chem. 2017, 89 (3), 2073−2079. (co-author)

5. Y. Zhuang, F. Huang, Q. Xu, M. Zhang, X. Lou*, F. Xia. Facile, Fast-Responsive, and Photostable Imaging of Telomerase Activity in Living Cells with a Fluorescence Turn-On Manner. Anal. Chem. 2016, 88 (6), 3289−3294.

6. Y. Zhuang^†, Q. Xu^†, F. Huang, P. Gao, Z. Zhao, X. Lou*, F. Xia. Ratiometric Fluorescent Bioprobe for Highly Reproducible Detection of Telomerase in Bloody Urines of Bladder Cancer Patients. ACS Sens. 2016, 1 (5), 572−578. (co-author)

7. Y. Zhuang, M. Zhang, B. Chen, R. Duan, X. Min, Z. Zhang, F. Zheng, H. Liang, Z. Zhao, X. Lou*, F. Xia. Quencher Group Induced High Specificity Detection of Telomerase in Clear and Bloody Urines by AIEgens. Anal. Chem. 2015, 87 (18), 9487−9493.

8. X. Lou^†, Y. Zhuang^†, X. Zuo^†, Y. Jia, Y. Hong, X. Min, Z. Zhang, X. Xu, N. Liu, F. Xia*, B. Z. Tang. Real-Time, Quantitative Lighting-up Detection of Telomerase in Urines of Bladder Cancer Patients by AIEgens. Anal. Chem. 2015, 87 (13), 6822−6827. (co-author)

9. X. Min^†, Y. Zhuang^†, Z. Zhang, Y. Jia, A. Hakeem, F. Zheng, Y. Cheng, B. Z. Tang, X. Lou*, F. Xia. Lab in a Tube: Sensitive Detection of MicroRNAs in Urine Samples from Bladder Cancer Patients Using a Single-Label DNA Probe with AIEgens. ACS Appl. Mater. Interfaces 2015, 7 (30), 16813−16818. (co-author)

10. Y. Jia^†, P. Gao^†, Y. Zhuang^†, M. Miao, X. Lou*, F. Xia. Facile Probe Design: Fluorescent Amphiphilic Nucleic Acid Probes without Quencher Providing Telomerase Activity Imaging Inside Living Cells. Anal. Chem. 2016, 88 (12), 6621−6626. (co-author)

发明专利情况：

一种用于非诊断用途的检测端粒酶活性的方法（ZL 2015 1 0445832.9）