个人简介：

张晓丹，韩国中央大学药学院生药学博士，硕士生导师。

研究方向：天然产物药效物质及生药资源开发与评价研究。拥有丰富的高校教学经验，主讲《药理学》、《生物药物分析》、《天然药物化学》等核心课程，教学效果优良。学术研究能力突出，主持国家重点研发计划子课题项目1项、省部级课题2项，中央本级重大增减支项目1项、担任地方研究院经理。在中文核心及SCI期刊发表论文60余篇，并出版学术专著4部。积极投身学术服务，现任浙江省营养学会理事，浙江药学会制药工程专委会和中药药理学专委会委员，在行业内具有一定影响力。  

办公室：6号楼607；

电话：15658050083

E-mail: zhangxiaodanzstu@163.com

学习工作经历：

2002年9月-2006年7月，中南大学，制药工程专业，本科；

2006年9月-2008年12月，中南大学，制药工程专业，研究生（保送），研究方向为天然药物化学；

2009年3月-2013年2月，韩国中央大学药学院生药学，博士（留基委公派留学）；

2013年07月2018年11月，浙江理工老员工命科学学院，讲师；

2018年11月至今，太阳成集团tyc151cc，副教授。

奖励荣誉：

大北农科技二等奖：优质大宗药材规范化生产关键技术及产业化应用（3/10）

中国商业联合会科学技术奖特等奖，复方丹参滴丸用优质丹参生产关键技术体系建立与产业化（10/13）

项目情况：

健脾益气浙产道地药材活性成分生物合成与调控机制解析(257万),国家自然科学基金委-联合基金-重点项目，2026.01-2029.12,主要参与人。

雁荡山铁皮石斛产业研究院筹建及合作项目（200万），乐清市农业农村局，2024.08-2025.12，主持。

名贵中药资源可持续利用能力建设项目-高含量甘油三油酸酯薏苡仁资源功能基因挖掘，中央本级重大增减支项目（60万），2022年-2024年，校内主持；

“新浙八味之三叶青”质量标志物及道地性特征挖掘关键技术研究，浙江省基础公益项目，2022-2025年，主持，到账经费：10万元；

次生代谢物质量控制与检测技术标准研究，国家级重点子课题（215万元），2016-2019年，校内主持，到账经费：28万元；

药用植物提取物及标准样品的制备关键技术研究（10万元），2019-2021年，主持；

基于Aβ25-35诱导PC12细胞氧化损伤保护作用的2种五加叶药效物质基础、构效关系及机制研究，浙江省自然科学基金，省部级一般，5万元，2014年，1/6，已结题；

太阳成集团tyc151cc科研启动基金，基于Aβ25-35诱导PC12 细胞氧化损伤保护作用的糙叶五加叶多酚类成分富集、构效关系及机制研究、2014/01-2016/12、3万元、在研、主持。

新型透皮吸收抗氧化药物的制备技术开发，横向，2015年，主持；

肿瘤靶标蛋白TNIK磷酸化促乳腺癌生长转移机制及其靶向抑制剂研究，国家级一般， 2016年，5/9；

负调控因子SmMYB39与正调控因子SmbHLH7协同调控丹参酚酸类成分生物合成的分子机制，国家级一般， 2016年，7/10；

铁皮石斛、三七、半夏转录组测序及开发应用，横向，130万元，3/8；

乳核散结胶囊标准提高及标准化建设项目，横向，20万元，3/5；

水果生产基地关键技术与示范推广技术服务，横向，48万元，4/5；

珍稀中药材高效组培繁育技术及相关产品开发，横向，20万元，10/10。

成果（论文/专利）：

1.Jie,Xia,Xinyu,He,Wan,Yang,Hongyan,Song,Jihong,Yang,Guoliang,Zhang,Zongqi,Yang,Haimin,Chen,Zongsuo,Liang,Larwubah,Kollie,Ann,Abozeid, Xiaodan,Zhang*,Zhenhao,Li*,Dongfeng,& Yang*.(2024).Unveiling the distribution of chemical constituents at different body parts and maturity stages of Ganoderma lingzhi by combining metabolomics with desorption electrospray ionization mass spectrometry imaging (DESI).Food Chemistry,436.(一区TOP IF: 10.4).

2.Jie Xia, Ganggui Lou, Lan Zhang, Yanbo Huang, Jian Yang, Juan Guo, Zhechen Qi, Zhenhao Li, Guoliang Zhang, Shengchun Xu, Xijiao Song, Xiaodan Zhang,*, Yukun Wei,*, Zongsuo Liang,*, Dongfeng Yang*. Unveiling the spatial distribution and molecular mechanisms of terpenoids biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omics and DESI-MSI. Horticulture Research, 2023, uhad109. doi:org/10.1093/hr/uhad109.(一区TOP IF: 8.7).

3.Lijun,Yang,Ruoqi,Jia,Hanjing,Sun,Ziying,Wang,Lingxia,Peng,Junqing,Wen,Zhiwei,Wang,Feng,Yin,Qiang,Miu,Xiaodan,& Zhang*.(2025).Effects of different drying methods on antioxidant activity, anti-inflammatory, anticancer and metabolome of Tetrastigma hemsleyanum Diels et Gilg.Industrial Crops and Products,233(一区TOP).

4.Lingxia Peng, Jiahao Fang, Lijun Yang, Gurusamy Abirami, Feng Yin, Lietao Cai, Chaojun Zhang, Yuyang Zhao, Yan Jin, Shuifeng Zhang, Huadong Sheng*, Guohong Zeng*, Haimin Chen*, Zongsuo Liang*, Xiaodan Zhang*,Analysis of the correlation between the distribution of microorganisms carried by Coix seed and fungal toxins, and the biological control of aflatoxin,Current Research in Food Science,Volume 10,2025,101040,ISSN 2665-9271,doi.org/10.1016/j.crfs.2025.101040.(一区TOP)

5.Jie Xia, Fei Yin, Min Lin, Zhongda Zeng, Jiani Yu,, Guanjun Hu, Qiang Miu, Qiuling He, Xiaodan Zhang*. Investigation on the Q-markers of D. nobile and D. chrysotoxum for anti-cancer and anti-inflammatory based on UPLC-Q-TOF-MS and spectrum-effect relationship. BMC Complementary Medicine and Therapies, 2023. doi: 10.1186/s12906-023-04048-y. IF: 3.9.

6.Jie Xia, Xiuyue Li, Min Lin, Jiani Yu, Zhongda Zeng, Fei Ye, Guanjun Hu, Qiang Miu, Qiuling He, Xiaodan Zhang*, Zongsuo Liang,*. Screening out biomarkers of Tetrastigma hemsleyanum for anti-cancer and anti-inflammatory based on spectrum-effect relationship coupled with UPLC-Q-TOF-MS.accepted. Molecules, 2023; 28(7):3021. doi:10.3390/molecules28073021. IF: 4.9.

7.Jiani Yu, Jie Xia, Jingxuan Xu, Shengliang Chen, Yan Zhang, Feng Yin, Jiahao Fang, Lietao Cai, Baohua Zhang, Yifei Zhan, Xiaodan Zhang*, Zhongda Zeng & Zongsuo Liang*.Chemical profile, anti-hepatoma activity, anti-acetylcholinesterase and antioxidant activity of aerial part of Aconitum carmichaeli Debx. Natural Product Research, 2022, 12:1-5. doi:10.1080/14786419.2022.2155821.

8.Xiu-Yue Li, Shu-Yao Li,Feng Yin,Hai-Min Chen, Dong-Feng Yang, Xiang-Qian Liu, Qing-Hao Jin,Xiao-Man Lv, Dennis Mans, Xiao-Dan Zhang* & Zong-Suo Liang*. Antioxidative and Cytoprotective Effects of Ganoderma applanatum and Fomitopsis pinicola in PC12 Adrenal Phaeochromocytoma Cells. International Journal of Medicinal Mushrooms,2022,24(10):15 -29.

9.Lijun Yang, Tinghui Feng, Lingxia Peng, Hongju Li, Zhiwei Wang, Lietao Cai, Chaojun Zhang, Yuyang Zhao, Yan Jin, Abirami Gurusamy, Dongfeng Yang*, Zongsuo Liang*, Xiaodan Zhang*,Genome-wide characterization of WRI1(WRINKLED1) gene family as a regulators of abiotic stress response in Coix (Coix lacryma-jobi L.),Plant Physiology and Biochemistry,Volume 227,2025,110195,ISSN 0981-9428,doi:10.1016/j.plaphy.2025.110195. IF：5.7

10.Peng, Lingxia，Hongju Li , Lijun Yang , Zongsuo Liang*, Xiaodan Zhang*. Exploring the Metabolic and Transcriptomic Profiles of Tetrastigma hemsleyanum for Tissue-Specific Compound Accumulation.  Frontiers in plant science vol. 16 1478061. 2 Apr. 2025, doi:10.3389/fpls.2025.1478061 IF：4.8

11.Tinghui Feng , Qiang Zhang, Tong Gao , Jiacong Gao, Jiahao Fang, Xiaodan Zhang*, Juane Dong* , Zongsuo Liang* (2025).Directed evolution of diacylglycerol acyltransferases 2 promotes lipids and triglyceride accumulation. Plant molecular biology, 115(1), 28. doi.org/10.1007/s11103-025-01552-2 IF：3.8

12.Lingxia Peng, Jiani Yu, Jiahao Fang, Feng Yin, Gurusamy Abirami, Jianxiong Wu, Ganggui Lou, Hongju Li, Lijun Yang, Jie Xia, Dongfeng Yang*, Zongsuo Liang*, Xiaodan Zhang*,Unveiling the phytochemical profile and biological potential of five Dendrobium species,Arabian Journal of Chemistry,Volume 17, Issue 9,2024,105922,ISSN 1878-5352,doi.org/10.1016/j.arabjc.2024.105922. IF：5.2

13.Zhongda Zeng, Jinfeng Huo, Yuxi Zhang, Yingjiao Shi, Zeying Wu, QianxuYang, Xiaodan Zhang*,Study on the correlation and difference of qualitative information among three types of UPLC-HRMS and potential generalization in metabolites annotation,Journal of Chromatography B,Volume 1243,2024,124219,ISSN 1570-0232,doi.org/10.1016/j.jchromb.2024.124219.

14.Lingxia Peng,Feng Yin，Xiuyue Li，Jiahao Fang，Hongju Li，Xinhan Xu，Pengguo Xia*，Zongsuo Liang*，Xiaodan Zhang*，UPLC-Q-TOF-MSE Based Profiling of the Chemical Composition of Different Parts of Tetrastigma hemsleyanum，2024，Natural Product Communications，2024，5，doi: 10.1177/1934578X241239494 IF:1.4

15.Jiahao Fang, Shuyao Li, Feng Yin, Lingxia Peng, Hongju Li, Lijun Yang, Qiang Miu, Zongsuo Liang*, Xiaodan Zhang*, Screening and Identification Quality Markers for Antioxidant Activity ofTetrastigma hemsleyanum from Different Origins using Spectrum-effectCorrelation Analysis, The Natural Products Journal;Volume 14, Issue 8, Year 2024, e010324227567.DOI: 10.2174/0122103155301912240228080042

16.Chen Jie，Xia Jie，Yin, Feng，Yu Jiani，Huo Jinfeng，Shi  Yingjiao，Han Ruilian，Zeng Zhongda，Xiaodan  Zhang*，UPLC-Q-Exactive-MS Combined with Network Pharmacology to Explore the Antitumor Effect of Polygonatum sibiricum Leaf Tea，Journal of Food Biochemistry.DOI:202310.1155/2023/4174625 IF：4.2

17.Hongju Li, Lingxia Peng, Feng Yin, Jiahao Fang, Lietao Cai, Chaojun Zhang, Zheng Xiang, Yuyang Zhao, Shuifeng Zhang, Huadong Sheng, Dekai Wang*, Xiaodan Zhang*, Zongsuo Liang*,Research on Coix seed as a food and medicinal resource, it's chemical components and their pharmacological activities: A review,Journal of Ethnopharmacology,Volume 319, Part 3,2024,117309,ISSN 0378-8741,doi.org/10.1016/j.jep.2023.117309. IF：5.4

18.俞佳妮，贾巧君，叶子弘，杨东风，侯卓妮，肖艺，张晓丹*.二氢丹参酮Ⅰ标准样品的研制.中国计量大学学报. 2021,2(32), 170-175.

19.娄港归,夏杰,杨健,王宏鹏,梁宗锁,肖艺,李振达,张煜,刘志超,施宛丽,张晓丹*,杨东风. 基于UPLC-Q-TOF-MS/MS代谢组学的铁皮石斛和玫瑰石斛化学成分差异研究.药学学报，2021, 56(12):14.

20.夏杰，贾巧君，叶子弘，杨东风，侯卓妮，肖艺，张晓丹*.丹参新酮标准样品的研制.湖南中医药大学学报. 2021，41（11）：1711-1716.

21.Xiaodan Zhang, Yesheng Cen, Zhechen Qi, Dongfeng Yang, Ziying Wang, Zhuoni Hou, Zongsuo Liang. Simultaneous determination of 17 constituents of Chinese wild Radix Salvia miltiorrhiza from different geographical areas by ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry, Current Phaemaceutical analysis, 2020, 3(16), 280-290.

22. Xiaodan Zhang#, Yange Yu#, Dongfeng Yang, Zhechen Qi, Ruizhen Liu, Fengtao Deng, Zengxuan Cai, Ying Li, Yanfang Sun*, and Zongsuo Liang*, Chemotaxonomic variation in secondary metabolites contents and their correlation between environmental factors in Salvia miltiorrhiza Bunge from natural habitat of China, IND CROP PROD, 2018, 113, 335-347.

23. Xiaodan Zhang#, Yange Yu#, Yesheng Cen, Dongfeng Yang, Zhechen Qi, Zhuoni Hou, Shuanglai Han, Zengxuan Cai, and Kuancheng Liu*, Bivariate Correlation Analysis of the Chemometric Profiles of Chinese Wild Salvia miltiorrhiza Based on UPLC-Qqq-MS and Antioxidant Activities, Molecules, 2018,23,538. [Doi:10.3390/molecules23030538]

24.  Gbago Onivogui, Xiaodan Zhang, Mohamed Diaby, Clotaire Gna Maomy, and Yuanda Song*, Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine, Brazilian Journal of Pharmaceutical Sciences, 2017, 53. [DOI: 10.1590/s2175-97902017000216040]

25. Xiaodan Zhang#, Zhi Li#, Guozhu Liu, Xiang Wang, Okkyoung Kwon, Hyeongkyu Lee, Wankyunn Whang, and Xiangqian Liu*, Quantitative determination of 15 bioactive triterpenoid saponins in different parts of Acanthopanax henryi by HPLC with charged aerosol detection and confirmation by LC-ESI-TOF-MS, Journal of seperation science, 2016, 39 (12), 2252-2262.

26. Xiaodan Zhang, Xinqi Zhou, Xiangqian Liu, Xiaolong Li, and Wankyunn Whang, Development and Application of an HPLC-UV Procedure to Determine Multiple Flavonoids and Phenolics in Acanthopanax Leaf Extracts, J CHROMATOGR SCI, 2015, 54 (4), 574-582.

27. Bingnan Han, Tingting Liang, Lawrence Jordan Keen, Tingting Fan, Xiaodan Zhang, Lin Xu, Qi Zhao, Shuping Wang, and Houwen Lin*, Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity, ORG LETT, 2018, 20,578-581.

28. Xiaojun Li, Ling Dai, Zhi Li., Xiaodan Zhang, Xiangqian Liu *, Qingpeng. Zou, and Xia Xie. Anti-inflammatory Activities of Lupane-triterpenoids In Vitro and Their Phytochemical Fingerprinting from Leaves of Acanthopanax gracilistylus, Natural Product Sciences,2015, 21(2) : 104-110.

29. Xiaojun Li, Weichao Huang, Zhi Li, Xiaodan Zhang, Xiangqian Liu * , Okkyoung Kwon, and Hyeongkyu Lee. Chemical Composition, Anti-inflammatory and Cytotoxic Activities of Essential Oils from Different Parts of Acanthopanax evodiaefolius. Nat Prod Res Dev 2015,27: 1156-1161.

30. Xiaodan Zhang, Xiangqian Liu, Y.H. Kim，and Wankyunn Whang* Chemical constituents in leaves of Acanthopanax henryi and antioxidant and acetyl cholinesterase inhibitory activities of some their major metabolites: A Potential Complementary Source against Alzheimer’s Disease. Archives of Pharmacal Research 2014,37(15):606-616.

31. Xiaodan Zhang#， Mihyue Oh，Seulgi Kim, Jimin Kim， Hyeyeon Kim， Sungun Kim， Peter J. Houghton，and Wankyunn Whang *. Epimediphine, a novel alkaloid from Epimedium koreanum inhibits acetylcholinesterase. Natural Product Research 2013, 27(12): 1067-1074.

32. 一种薏苡抗盐胁迫相关基因ClWRI1-20及其应用，张晓丹，杨丽君等，专利号ZL202510033150.0；

33. 一种用于白簕中总多酚纯化的大孔树脂的制备方法, 张晓丹,侯卓妮，梁宗锁，汪紫莹，陈盛良，胡心怡，专利号ZL201710564644.7；

34. 附子地上部分总生物碱的制备方法及用途，张晓丹,梁宗锁，杨东风，陈盛良，张岩，专利号ZL 2020 1 0755742.0；

35. 中华人民共和国国家标准样品：丹参新酮 (GSB 11-3803-2020) ，国家标准化管理委员会；

36. 中华人民共和国国家标准样品：二氢丹参酮І (GSB 11-3804-2020)，国家标准化管理委员会.

37. 韩国圆光出版社：《人畜通用中药材》，张晓丹（副主编）.

员工培养情况：

已指导硕士研究生8名，其中3人荣获国家奖学金，2人获得省级优秀实践成果奖，培养质量高；

2020级硕士研究生夏杰获得了浙江省专业学位研究生优秀实践成果；

2022级硕士研究生彭玲霞获得了太阳成集团tyc151cc2025年优秀研究生论文；

2022级硕士研究生彭玲霞获得了浙江省专业学位研究生优秀创新成果A级；

2020级硕士研究生夏杰获得了武汉大学免试博士入学资格；

2022级硕士研究生彭玲霞获得了中山大学免试博士入学资格；

指导研究生获得中国研究生乡村振兴科技强农+创新大赛团队二等奖。