个人简介

于威，博士，教授，博（硕）士生导师。2001.06博士毕业于浙江大学动物科学学院经济动物饲养专业，2001.12-2005.08在日本杏林大学医学部高龄医学研究室从事博士后研究工作。曾获“浙江省高校优秀教师”，浙江省“新世纪151人才工程”第三层次培养人员，太阳成集团tyc151cc首批“521”中青年骨干人才等称号，浙江省线上一流本科课程、省课程思政示范课程负责人。主持（完成）国家863重点项目、国家自然科学基金（面上）、浙江省自然科学基金（面上）、浙江省钱江人才计划等多个科研项目，累积到账经费超过2000余万元。主持完成省级教改项目3项及校级教改项目多项。长期从事蛋白质翻译后修饰组学和昆虫杆状病毒分子生物学方面的研究，发表SCI收录论文50余篇，（合作）申请国家发明专利2项。

近年主持的科研项目：

（1） 国家自然科学基金委员会，面上项目，31972623, 乙酰化修饰对家蚕热休克蛋白Hsp70s功能的影响及其调控杆状病毒侵染的分子机制，2020.01-2023.12，68万元，主持，在研

（2）浙江省自然科学基金委，面上项目，LY17C170006，家蚕Hn1L蛋白在杆状病毒侵染过程中调控机制的研究，2017.01-2019.12，主持，已结题

近年代表性论著：

1. Chaoguang Gu, Yuqian Mo, Jiaqi Li, Xizhen Zhang, Siqi Xu, Meng Miao, Yanping Quan, Wei Yu*. LEF3 phosphorylation attenuates the replication of Bombyx mori nucleopolyhedrovirus by suppressing its interaction with alkaline nuclease. Virology, 2025, 603, 110369.

2. Xizhen Zhang, Shiyi Ma, Chaoguang Gu, Miao Hu, Meng Miao, Yanping Quan, Wei Yu*. K64 acetylation of heat shock protein 90 suppresses nucleopolyhedrovirus replication in Bombyx mori. Archives of Insect Biochemistry and Physiology, 2024, 115: e22079.

3. Miao Hu, Yi You, Yao Li, Shiyi Ma, Jiaqi Li, Meng Miao, Yanping Quan, Wei Yu*. Deacetylation of ACO2 is essential for inhibiting Bombyx mori nucleopolyhedro- virus propagation. Viruses, 2023, 15, 2084.

4. Miao Hu, Yajie Zhu, Yuqian Mo, Xu Gao, Meng Miao, Wei Yu*. Acetylation of citrate synthase inhibits Bombyx mori nucleopolyhedrovirus propagation by affecting energy metabolism. Microbial Pathogenesis, 2022, 173: 105890.

5. Xizhen Zhang, Wei Yu*. Heat shock proteins and viral infection. Frontiers in Immunology, 2022, 947789.

6. Xu Gao, Siqi Xu, Yuqian Mo, Yajie Zhu, Xi Chen, Meng Miao, Yanping Quan, Wei Yu*. Acetylation of fructose-bisphosphate aldolase-mediated glycolysis is essential for Bombyx mori nucleopolyhedrovirus infection. Microbial Pathogenesis, 2022, 170: 105695.

7. Yajie Zhu, Miao Hu, Jonas Ngowo, Xu Gao, Xi Chen, Huihui Yan, Wei Yu*. Deacetylation of BmAda3 is required for cell apoptosis caused by Bombyx mori nucleopolyhedrovirus infection. Archives of Insect Biochemistry and Physiology, 2021, e21838.

8. Fuxiang Mao, Xi Chen, Jonas Ngowo, Yajie Zhu, Jihai Lei, Xu Gao, Meng Miao, Yanping Quan, Wei Yu*. Deacetylation of HSC70-4 promotes Bombyx mori nucleopolyhedrovirus proliferation via proteasome-mediated nuclear import. Frontiers in Physiology, 2021, 12:609674.

9. Fuxiang Mao, Yajie Zhu, Xu Gao, Xi Chen, Jonas Ngowo, Meng Miao, Yanping Quan, Wei Yu*. HSP/HSC70 activity is required for Bombyx mori ucleopolyhedrovirus replication at the early infectious phase. Microbial Pathogenesis, 2021, 153: 104647.

10. Xu Gao, Jihai Lei, Yajie Zhu, Xi Chen, Fuxiang Mao, Meng Miao, Yanping Quan,  Wei Yu*. Role of the Bombyx mori nucleopolyhedrovirus LEF3 acetylation on viral replication. Microbial Pathogenesis, 2021, 158: 105109.